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Symbol
Name
ID 		Ifng
interferon gamma
MGI:107656
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Decreased circulating IgA level
Decreased circulating IgG level
Decreased circulating IgG2 level
Defective B cell differentiation
Bleeding with minor or no trauma
Epistaxis
Gingival bleeding
Gastrointestinal hemorrhage
Hematemesis
Melena
Intracranial hemorrhage
Intraventricular hemorrhage
Joint hemorrhage
Muscle hemorrhage
Oral cavity bleeding
Persistent bleeding after trauma
Bruising susceptibility
Purpura
Petechiae
Spontaneous hematomas
Bone marrow hypocellularity
Pancytopenia
Aplastic anemia
Anemia
Abnormal B cell count
Decreased proportion of CD4-positive helper T cells
T lymphocytopenia
Lymphopenia
Leukocytosis
Abnormality of neutrophils
Hemophagocytosis
Leukemia
Acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemias
Arterial thrombosis
Thromboembolism
Reduced factor VIII activity
Prolonged partial thromboplastin time
Abnormality of thrombocytes
Thrombocytosis
Lymphoma
Hodgkin lymphoma
Non-Hodgkin lymphoma
Elevated erythrocyte sedimentation rate
Splenic rupture
Splenomegaly
Hepatosplenomegaly
Disease(s) Associated with IFNG
acute lymphoblastic leukemia
aplastic anemia
ataxia telangiectasia
chronic granulomatous disease
factor VIII deficiency
graft-versus-host disease
immunodeficiency 69
rheumatoid arthritis
temporal arteritis

Mouse Phenotypes
abnormal dendritic cell chemotaxis
abnormal macrophage chemotaxis
abnormal diapedesis
increased splenocyte proliferation
abnormal uterine NK cell morphology
increased uterine NK cell number
thymus atrophy
enlarged spleen
decreased common myeloid progenitor cell number
abnormal erythropoiesis
abnormal B cell differentiation
extramedullary hematopoiesis
anemia
impaired hematopoiesis
abnormal bone marrow cell morphology/development
decreased myeloid cell number in bone marrow
decreased bone marrow cell number
decreased granulocyte monocyte progenitor cell number
decreased megakaryocyte cell number
decreased erythroid progenitor cell number
abnormal proerythroblast morphology
increased erythroblast number
decreased erythrocyte cell number
increased hematocrit
increased nucleated erythrocyte cell number
increased neutrophil cell number
increased granulocyte number
thrombocytopenia
decreased mature B cell number
decreased pre-B cell number
increased CD8-positive, alpha-beta T cell number
increased NK T cell number
increased T cell number
increased lymphocyte cell number
increased macrophage cell number
increased monocyte cell number
decreased leukocyte cell number
increased leukocyte cell number
pancytopenia
increased hematopoietic stem cell number
abnormal hematopoietic stem cell morphology
decreased megakaryocyte-erythroid progenitor cell number
abnormal spleen morphology
abnormal spleen red pulp morphology
spleen atrophy
abnormal spleen white pulp morphology
pale spleen
abnormal B cell physiology
abnormal immunoglobulin level
decreased IgA level
decreased IgE level
increased IgE level
increased IgG1 level
decreased IgG2a level
decreased IgG2b level
decreased IgG3 level
decreased IgG level
decreased IgM level
decreased immunoglobulin level
abnormal NK cell physiology
impaired natural killer cell mediated cytotoxicity
abnormal uterine NK cell physiology
abnormal cytotoxic T cell physiology
abnormal T cell activation
abnormal macrophage physiology
abnormal MHC II cell surface expression on macrophages
Availability Mouse Genotype
Ifngtm1.1Hayg/Ifngtm1.1Hayg
Ifngtm1Ts/Ifngtm1Ts
Ifngtm1.1(KOMP)Vlcg/Ifng+
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory